Seasonal Differences in Paediatric Hodgkin's Lymphoma
Author Information
Author(s): Reiman A, Powell J E, Flavell K J, Grundy R G, Mann J R, Parkes S, Redfern D, Young L S, Murray P G
Primary Institution: University of Birmingham
Hypothesis
Are seasonal effects associated with EBV status in paediatric Hodgkin's lymphoma?
Conclusion
EBV-positive paediatric Hodgkin's lymphoma shows a significant peak in symptom onset during the summer months.
Supporting Evidence
- EBV-positive patients showed a significant peak in symptom onset during July/August.
- EBV-negative patients were more likely to report symptoms in the winter months.
- The study analyzed 172 cases of Hodgkin's lymphoma in children.
- Statistical analysis revealed significant seasonal trends for EBV-positive cases.
Takeaway
Kids with a certain type of cancer called Hodgkin's lymphoma are more likely to show symptoms in the summer if they have a virus called EBV.
Methodology
The study analyzed cases of histologically confirmed Hodgkin's lymphoma in children diagnosed in the West Midlands, UK, from 1957 to 2001, examining symptom onset and EBV status.
Potential Biases
Potential biases in recording or recall of symptom onset dates.
Limitations
The study relied on historical data, which may have inaccuracies in symptom onset reporting.
Participant Demographics
Children under 15 years diagnosed with Hodgkin's lymphoma.
Statistical Information
P-Value
0.005
Statistical Significance
p=0.005
Digital Object Identifier (DOI)
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