Detecting 50 Antibiotic Residues in Plasma
Author Information
Author(s): Hu Jun, Ba Yina, Pan Zhifeng, Li Xiaogang
Primary Institution: Shanghai Electric Power Hospital
Hypothesis
Can we develop a reliable method to detect multiple antibiotic residues in human plasma simultaneously?
Conclusion
The developed method can accurately detect 50 types of antibiotics in human plasma, demonstrating its feasibility and reliability.
Supporting Evidence
- The method can detect antibiotics with a recovery rate between 67.25% and 129.03%.
- Limit of detection values ranged from 0.1 ng/ml to 5 ng/ml for various antibiotics.
- The method was validated on 80 patient samples, showing good application value.
Takeaway
Scientists created a new way to find 50 different antibiotics in blood quickly and accurately, which helps keep people safe from harmful drug residues.
Methodology
The study used HPLC-MS/MS to analyze plasma samples for antibiotic residues, optimizing sample preparation and chromatographic conditions.
Limitations
The method's accuracy may vary depending on the pH of specific antibiotics, which could influence recovery values.
Participant Demographics
Participants were healthy individuals enrolled from Shanghai Electric Power Hospital between March 2022 and June 2023.
Digital Object Identifier (DOI)
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