SGK1 Gene Variance and Insulin Secretion in European Populations
Author Information
Author(s): Friedrich Björn, Weyrich Peter, Stančáková Alena, Wang Jianjung, Kuusisto Johanna, Laakso Markku, Sesti Giorgio, Succurro Elena, Smith Ulf, Hansen Torben, Pedersen Oluf, Machicao Fausto, Schäfer Silke, Lang Florian, Risler Teut, Ullrich Susanne, Stefan Norbert, Fritsche Andreas, Häring Hans-Ulrich
Primary Institution: University of Tübingen
Hypothesis
SGK1 is involved in the regulation of insulin secretion and may represent a candidate gene for the development of type 2 diabetes mellitus in humans.
Conclusion
The SGK genotype rs9402571 is associated with increased insulin secretion in lean non-diabetic individuals and lower diabetes prevalence.
Supporting Evidence
- Carriers of the minor G allele in rs9402571 had significantly higher C-peptide levels in the 2 h OGTT.
- The effect on insulin secretion was significant only in lean participants.
- The findings were replicated in the EUGENE2 cohort.
- The METSIM trial showed a lower prevalence of type 2 diabetes in rs9402571 minor allele carriers.
Takeaway
This study found that a specific gene variant helps lean people produce more insulin, which may protect them from diabetes.
Methodology
Three independent European populations were analyzed for the association of SGK1 gene variations and insulin secretion traits using genetic analysis and oral glucose tolerance tests.
Limitations
The study's findings may not apply to overweight or obese individuals as the effects were only significant in lean participants.
Participant Demographics
The study included non-diabetic individuals from three European cohorts, with varying ages and BMI.
Statistical Information
P-Value
0.04
Confidence Interval
95%CI: 0.71–1.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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