Genetic Factors Affecting C-Reactive Protein Levels in North Indians
Author Information
Author(s): Mahajan Anubha, Tabassum Rubina, Chavali Sreenivas, Dwivedi Om Prakash, Chauhan Ganesh, Ghosh Saurabh, Tandon Nikhil, Bharadwaj Dwaipayan
Primary Institution: CSIR-Institute of Genomics and Integrative Biology, Delhi, India
Hypothesis
The study investigates the genetic determinants of high sensitivity C-reactive protein (hsCRP) levels in the North Indian population.
Conclusion
The study identified two significant genetic variants, rs3093059 in CRP and rs1892534 in LEPR, that contribute to the variance in hsCRP levels in the North Indian population.
Supporting Evidence
- The study found significant associations of 12 genetic variants with hsCRP levels.
- The cis-acting variant rs3093059-CRP contributed maximally to hsCRP level variance.
- The trans-acting variant rs1892534-LEPR was also significantly associated with hsCRP levels.
- The associations were confirmed through replication in an independent sample.
- Meta-analysis further strengthened the associations for both variants.
Takeaway
Scientists found that certain genes can change the amount of a protein in the blood that shows inflammation, which can help understand health risks in people from North India.
Methodology
The study evaluated genetic variants associated with hsCRP levels in 4,200 North Indians, using linear regression and replication in an independent sample.
Potential Biases
Potential population stratification was minimized by including only North Indian subjects of Indo-European ethnicity.
Limitations
The study may have limited statistical power for variants with small effect sizes and could not type some variants due to assay failures.
Participant Demographics
The study included 2,115 unrelated Indo-Europeans (1,073 T2D patients and 1,042 non-diabetic subjects) and an independent set of 2,085 samples.
Statistical Information
P-Value
p=9.6×10−5 for rs3093059-CRP and p=5.5×10−3 for rs1892534-LEPR
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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