Insulin-like Growth Factor I and Diabetic Retinopathy
Author Information
Author(s): John F. Payne, Vin Tangpricha, Julia Cleveland, Michael J. Lynn, Robin Ray, Sunil K. Srivastava
Primary Institution: Emory University
Hypothesis
What is the relationship between serum insulin-like growth factor I (IGF-I) and diabetic retinopathy?
Conclusion
This study found no association between serum IGF-I levels and diabetic retinopathy.
Supporting Evidence
- Diabetic subjects had similar serum IGF-I concentrations compared to nondiabetic subjects.
- There was no significant difference in mean serum IGF-I levels among the study groups.
- The study found no association between serum IGF-I levels and diabetic retinopathy.
Takeaway
The study looked at whether a substance called IGF-I in the blood is linked to eye problems in people with diabetes, and it found that there is no connection.
Methodology
A clinic-based cross-sectional study with 225 subjects classified into four groups based on diabetes status and retinopathy findings.
Limitations
The cross-sectional design limited the ability to assess causality, and only one time point was recorded for the subjects.
Participant Demographics
Subjects included 99 without diabetes, 42 with diabetes but no retinopathy, 41 with nonproliferative diabetic retinopathy, and 43 with proliferative diabetic retinopathy.
Statistical Information
P-Value
0.497
Statistical Significance
p=0.897
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