HLA-B*57 and Gender Influence Tuberculosis in HIV Infected People
Author Information
Author(s): Jagannathan Latha, Chaturvedi Mrinalini, Satish Bhuthaiah, Satish Kadappa Shivappa, Desai Anita, Subbakrishna D. K., Satishchandra Parthasarathy, Pitchappan Ramasamy, Balakrishnan Kamala, Kondaiah Paturu, Ravi Vasanthapuram
Primary Institution: Rotary-TTK Blood Bank, Bangalore Medical Services Trust
Hypothesis
Does the presence of HLA-B*57 and gender influence the occurrence of tuberculosis in HIV infected individuals?
Conclusion
HIV positive women with HLA-B*57 have a lower occurrence of tuberculosis compared to men.
Supporting Evidence
- The incidence of TB was lower in females (12.6%) than in males (25.6%).
- HLA-B*57 frequency was significantly higher among females without TB (21.6%) compared to males (1.7%).
- CD4 counts were higher among females in the cohort.
Takeaway
This study found that women with a specific gene (HLA-B*57) are less likely to get tuberculosis when they have HIV compared to men.
Methodology
A cohort of 238 HIV seropositive subjects were followed for 5 years, with HLA typing and TB diagnosis based on clinical and laboratory criteria.
Potential Biases
Potential bias due to self-reporting of HIV infection duration and lack of control for other confounding factors.
Limitations
The study did not have a separate control group for comparison and relied on a database of healthy renal donors.
Participant Demographics
238 HIV positive individuals, 50.4% male and 49.6% female, with a median age of 30 years.
Statistical Information
P-Value
0.0046
Statistical Significance
p = 0.0046
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website