Analysis of variation in NF-κB genes and expression levels of NF-κB-regulated molecules

2007

Study of NF-κB Genes and Their Role in Gene Expression

Sample size: 42 publication Evidence: moderate

Author Information

Author(s): Liu-Mares Wen, Sun Zhifu, Bamlet William R, Atkinson Elizabeth J, Fridley Brooke L, Slager Susan L, de Andrade Mariza, Goode Ellen L

Primary Institution: Mayo Clinic College of Medicine

How do variations in NF-κB genes affect the expression levels of NF-κB-regulated proteins?

Variation in the genes encoding p50 and c-Rel may influence the transcription of proteins involved in apoptosis and immune response.

Linkage analysis showed associations between NFKB1 and FAS, IRF1 expression.
Family-based association tests suggested associations with CD40, BCL2A1, and MYC expression levels.
Single-SNP association testing was less conservative than haplotype and FBAT analysis.

This study looked at how changes in certain genes might affect how our body controls cell death and immune responses.

The study used association, linkage, and family-based association analyses on genetic data from pedigrees.

The results may not be reliable due to the small sample size and lack of adjustment for multiple tests.

The study had a small sample size and did not adjust for multiple comparisons.

Participants were Utah residents with ancestry from northern and western Europe.

0.0003

p<0.05

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