Trans-Septal Lead Implant for Heart Failure Treatment
Author Information
Author(s): Farhangee Arsalan, Davies Mark J., Gaughan Katie, Mesina Mihai, Mîndrilă Ion, Fazio Serafino
Primary Institution: Department of Cardiology, Milton Keynes University Hospital, UK
Hypothesis
Is trans-septal endocardial left ventricle lead placement an effective alternative for patients with heart failure and challenging coronary sinus anatomy?
Conclusion
Trans-septal left ventricular endocardial lead implantation is safe and improves heart function, but carries a higher risk of stroke.
Supporting Evidence
- The study showed a significant improvement in left ventricular ejection fraction after the procedure.
- Patients reported a decrease in their New York Heart Association class after the lead implantation.
- Post-implantation, NTproBNP levels significantly decreased, indicating improved heart function.
- Despite improvements, the study noted a 9% incidence of stroke among patients.
Takeaway
This study shows that a special heart lead can help patients with heart failure feel better, but it might also cause some strokes.
Methodology
This was a single-center cohort study evaluating the safety and efficacy of trans-septal left ventricular endocardial lead implants in patients with a failed coronary sinus lead.
Potential Biases
The study's retrospective nature may introduce selection bias.
Limitations
This is a retrospective study with potential biases and limited follow-up data.
Participant Demographics
The median age of participants was 76 years, with a majority being male (81%).
Statistical Information
P-Value
0.0049
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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