1-Benzyl-3,5-bis(4-methylbenzylidene)-4-oxopiperidin-1-ium chloride acetic acid monosolvate
2011
Study of a New Organic Compound
publication
Author Information
Author(s): Sun Ju-feng, Xing Juan, Han Jing-tian
Primary Institution: Binzhou Medical College
Conclusion
The compound shows potential as a basic unit for developing antineoplastic drugs.
Supporting Evidence
- The compound has an IC50 of 59.80 µM against HL-60 cells.
- The compound has an IC50 of 105.09 µM against HSC-2 cells.
- It is a lead tumor-specific cytotoxin that induces apoptosis and autophagy.
Takeaway
Researchers created a new chemical compound that might help make better cancer drugs.
Methodology
The compound was synthesized using a reaction of N-benzyl-4-piperidone and p-tolualdehyde in acetic acid.
Digital Object Identifier (DOI)
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