Anticoagulant Activity of Abalone Gonad Polysaccharide
Author Information
Author(s): Liu Qinhao, Yao Siyu, Ma Siyuan, Zhao Ting, Wang Zhenyu, Sun Liming, Du Ming, Michaud Philippe
Primary Institution: National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University
Hypothesis
The study investigates the role of conjugate protein on the anticoagulant activity of abalone gonad polysaccharide.
Conclusion
The conjugate protein positively influences the anticoagulant activity of abalone gonad polysaccharide.
Supporting Evidence
- AGP extracts significantly prolonged activated partial thromboplastin time (APTT) and thrombin time (TT).
- The strongest anticoagulant activity was observed in female AGPs prepared at 50 and 121 °C.
- Defatting lowered the activity of female AGP but increased that of males.
- Proteolysis significantly weakened the clotting factor inhibition effect of the 50 °C female AGP.
Takeaway
This study found that a special protein in abalone gonad helps make a substance that can stop blood from clotting.
Methodology
The study involved extracting polysaccharides from abalone gonads and testing their anticoagulant activity through various treatments and assays.
Limitations
The study does not specify the exact mechanisms by which the conjugate protein enhances anticoagulant activity.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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