Up-regulation of Tissue Factor in Human Pulmonary Artery Endothelial Cells after Ultrafine Particle Exposure
2007
Impact of Ultrafine Particles on Endothelial Cells
Sample size: 8
publication
Evidence: moderate
Author Information
Author(s): Karoly Edward D., Li Zhuowei, Dailey Lisa A., Hyseni Xhevahire, Huang Yuh-Chin T.
Primary Institution: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency
Hypothesis
Ultrafine particles would cause endothelial cell dysfunction.
Conclusion
Ultrafine particles may induce vascular endothelial cells to express genes related to clotting, suggesting potential adverse cardiovascular health effects.
Supporting Evidence
- 320 genes were up-regulated and 106 down-regulated after exposure to ultrafine particles.
- Significant up-regulation of tissue factor (F3) was observed.
- UFP exposure increased the release of interleukin (IL)-6 and IL-8.
Takeaway
When tiny particles from pollution get into our lungs, they can make our blood vessels act funny and might lead to heart problems.
Methodology
Gene expression profiling of human pulmonary artery endothelial cells exposed to ultrafine particles for 4 hours.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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