Effect of Stress on Viral-Bacterial Synergy in Bovine Respiratory Disease
Author Information
Author(s): P. D. Hodgson, P. Aich, A. Manuja, K. Hokamp, F. M. Roche, F. S. L. Brinkman, A. Potter, L. A. Babiuk, P. J. Griebel
Primary Institution: Vaccine and Infectious Disease Organization, University of Saskatchewan
Hypothesis
Stress significantly alters the viral-bacterial synergy resulting in fatal bovine respiratory disease.
Conclusion
Stress can modulate the severity of bovine respiratory disease through complex interactions with viral and bacterial infections.
Supporting Evidence
- Stressors like transport and social reorganization can increase the risk of respiratory disease in calves.
- Elevated serum corticosteroid levels can alter immune function and affect disease outcomes.
- Different types of stress can have varying effects on the severity of respiratory infections.
Takeaway
When cows get stressed, it can make them more likely to get really sick from infections that come after a virus.
Methodology
The study used a disease model involving a primary bovine herpesvirus-1 infection followed by a secondary challenge with Mannheimia haemolytica.
Limitations
The study did not investigate the interaction between stress and viral-bacterial synergy in respiratory disease in detail.
Participant Demographics
The study focused on weaned beef calves.
Digital Object Identifier (DOI)
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