Integrons in the Age of Antibiotic Resistance: Evolution, Mechanisms, and Environmental Implications: A Review
2024

Integrons and Antibiotic Resistance

publication 10 minutes Evidence: high

Author Information

Author(s): Ali Niyaz, Ali Izhar, Din Ahmad Ud, Akhtar Kashif, He Bing, Wen Ronghui

Primary Institution: State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bio-Resources, Guangxi University

Hypothesis

Integrons play a significant role in the acquisition and dissemination of antibiotic resistance genes in various environments.

Conclusion

Integrons are crucial in the spread of antibiotic resistance across different ecosystems, influenced by human activities.

Supporting Evidence

  • Integrons are found in various environments, including clinical and agricultural settings.
  • Over 130 different resistance genes have been identified within integrons.
  • Integrons facilitate horizontal gene transfer among bacteria, contributing to the spread of antibiotic resistance.

Takeaway

Integrons are like tiny genetic tools that help bacteria share their resistance to antibiotics, making it harder to treat infections.

Methodology

This review synthesizes existing literature on integrons, their structure, function, and role in antibiotic resistance.

Limitations

The review is based on existing literature and may not cover all recent developments in the field.

Digital Object Identifier (DOI)

10.3390/microorganisms12122579

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