Combination chemotherapy for choroidal melanoma
Author Information
Author(s): Neale M H, Myatt N, Cree I A, Kurbacher C M, Foss A J E, Hungerford J L, Plowman P N
Primary Institution: Institute of Ophthalmology, Department of Pathology, Bath Street, London, EC1V 9EL, UK
Hypothesis
The study examines the sensitivity of choroidal melanoma to combinations of chemotherapy agents.
Conclusion
The combination of treosulfan with gemcitabine or cytosine arabinoside shows significant activity against primary choroidal melanoma tissue.
Supporting Evidence
- The combination of treosulfan with gemcitabine showed consistent activity in 70% of cases.
- The combination of treosulfan with cytosine arabinoside showed consistent activity in 86% of cases.
- Paclitaxel was active in combination with treosulfan in 47% of cases.
Takeaway
Doctors tested different medicines to see which ones work best for a type of eye cancer, and found that some combinations worked really well.
Methodology
Tumour material from enucleated eyes was tested against various single agents and combinations using an ATP-based tumour chemosensitivity assay.
Limitations
The study could not examine metastatic tumour from choroidal melanoma patients.
Digital Object Identifier (DOI)
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