The Role of HOXD9 in Gliomas and Cancer Stem Cells
Author Information
Author(s): Tabuse Masanao, Ohta Shigeki, Ohashi Yohei, Fukaya Raita, Misawa Aya, Yoshida Kazunari, Kawase Takeshi, Saya Hideyuki, Thirant Cécile, Chneiweiss Hérve, Matsuzaki Yumi, Okano Hideyuki, Kawakami Yutaka, Toda Masahiro
Primary Institution: Keio University School of Medicine
Hypothesis
HOXD9 contributes to cell proliferation and survival in gliomas and glioma cancer stem-like cells.
Conclusion
HOXD9 may serve as a novel marker for glioma cancer stem cells and a potential therapeutic target.
Supporting Evidence
- HOXD9 was highly expressed in glioma cell lines and human glioma tissues.
- Silencing HOXD9 led to decreased cell proliferation and induced apoptosis in glioma cells.
- HOXD9 expression was higher in glioma cancer stem cells compared to normal astrocytes.
Takeaway
HOXD9 is a gene that helps glioma cells grow and survive, and targeting it could help treat brain tumors.
Methodology
The study involved quantitative real-time PCR, immunohistochemistry, and siRNA treatment to analyze HOXD9 expression and function in glioma cells.
Limitations
The study did not establish a direct correlation between HOXD9 expression and tumor grade or proliferation index.
Participant Demographics
Patients with glioma who underwent surgery at Keio University and Paris Descartes University.
Statistical Information
P-Value
2.93E-10
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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