Parvovirus B19 Infection in Children with Blood Cancers
Author Information
Author(s): Kishore Janak Sen, Manodeep Kumar, Ashutosh Kumar, Archana
Primary Institution: Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Hypothesis
What is the frequency and impact of parvovirus B19 infection in children with newly diagnosed haematological malignancies?
Conclusion
Parvovirus B19 infection is common in children with acute lymphoblastic leukaemia and can lead to unexplained anaemia and delays in chemotherapy.
Supporting Evidence
- 17.1% of children with haematological malignancies were found to be infected with B19.
- B19 infected children required more blood transfusions compared to uninfected children.
- 60% of B19 infected children experienced delays in induction chemotherapy.
Takeaway
Some kids with blood cancers can get sick from a virus called parvovirus B19, which can make them feel worse and delay their treatment.
Methodology
The study involved 35 children with haematological malignancies and 34 controls, testing for B19 infection using serological and molecular methods.
Limitations
The study had a small sample size and some children were lost to follow-up.
Participant Demographics
35 children aged under 12 years, predominantly male (29 males, 6 females).
Statistical Information
P-Value
p<0.02
Statistical Significance
p<0.05
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