Resistance of Human T Cells to Cyclophosphamide
Author Information
Author(s): J.E. Byfield, P.M. Calabro-Jones
Primary Institution: University of California San Diego
Hypothesis
Do human T colony-forming units (T-CFUcs) exhibit resistance to activated cyclophosphamide similar to critical marrow stem cells?
Conclusion
Human T cells show significant resistance to activated cyclophosphamide, which may explain the differential effects observed in vivo.
Supporting Evidence
- The study shows that T-CFUcs are virtually unaffected by phosphoramide mustard at cytotoxic levels for other cells.
- Resistance to activated cyclophosphamide may explain the histological manifestations of treatment in vivo.
- Some human T cell functions can still be inhibited by activated cyclophosphamide, indicating that resistance is not universal.
Takeaway
This study found that some human T cells can survive a drug that usually kills other cells, which might help doctors understand how to treat cancers better.
Methodology
The study used a quantitative colony assay technique to examine the effect of phosphoramide mustard on T lymphocytes.
Limitations
The study does not clarify the exact mechanism of resistance in T cells.
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