Effects of Statins and Fibrates on Lipoprotein Ratios
Author Information
Author(s): Chan Sammy Y, Mancini GB John, Ignaszewski Andrew, Frohlich Jiri
Primary Institution: University of British Columbia
Hypothesis
How do statins and fibrates affect lipoprotein subclasses in patients with hyperlipidemia?
Conclusion
Simvastatin significantly reduced the atherogenic to anti-atherogenic lipoprotein ratio, while fenofibrate did not.
Supporting Evidence
- Simvastatin reduced LDL particle concentration by 32%.
- Fenofibrate increased large LDL particle size by 17%.
- Simvastatin had no effect on HDL particle size.
- LDL-P/HDL-P ratio was significantly reduced by simvastatin.
Takeaway
This study looked at how two types of cholesterol-lowering medicines, statins and fibrates, change the types of cholesterol particles in the blood. Statins worked better at improving the balance of good and bad cholesterol particles.
Methodology
A crossover study where 35 subjects were treated with simvastatin and fenofibrate sequentially, with assessments of lipoprotein subclasses using NMR spectroscopy.
Potential Biases
None reported.
Limitations
The study had a relatively small sample size and potential carryover effects from the crossover design.
Participant Demographics
35 subjects, 21 males, mean age 60 ± 12 years.
Statistical Information
P-Value
p < 0.001 for simvastatin vs fenofibrate
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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