Oestrogen Receptor Isoforms and Progesterone Receptor Levels in Breast Cancer
Author Information
Author(s): V.A. Baker, J.R. Puddefoot, S. Marsigliante, S. Barker, A.W. Goode, G.P. Vinson
Primary Institution: Queen Mary and Westfield College (University of London)
Hypothesis
The variability in the profile of oestrogen receptor isoforms is related to progesterone receptor levels in breast cancer tumors.
Conclusion
The study found that the presence of multiple oestrogen receptor isoforms correlates with higher levels of progesterone receptors in breast cancer tumors.
Supporting Evidence
- 97.0% of tumors contained the isoform at pI 6.6.
- 83.3% of tumors contained the isoform at pI 6.1.
- 39.4% of tumors contained the isoform at pI 6.3.
- 33.3% of tumors contained the isoform at pI 6.8.
- Only 12.1% of tumors contained all four ER isoforms.
Takeaway
This study looked at breast cancer tumors to see how different types of oestrogen receptors relate to progesterone receptors, finding that more types of oestrogen receptors usually mean more progesterone receptors.
Methodology
The study used high resolution isoelectric focusing to analyze oestrogen receptor isoforms and measured progesterone receptor levels in breast tumor samples.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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