The Effects on Toxicity of Circadian Patterning of Continuous Hepatic Artery Infusion
1992
Effects of Timing on Toxicity in Hepatic Artery Infusion
Sample size: 34
publication
Evidence: moderate
Author Information
Author(s): M. Margaret Kemeny, Galo Alava, Jorge M. Oliver, Fred B. Smith
Primary Institution: St. Vincent's Hospital and Medical Center
Hypothesis
Does the timing of continuous hepatic artery infusion affect its toxicity?
Conclusion
Changing the timing of drug infusion can significantly reduce toxicity in rats.
Supporting Evidence
- All rats on a constant infusion died within 9.3 days.
- All rats on a day cycle survived 14 days.
- Rats on a night cycle died within 5.5 days.
Takeaway
When giving medicine through a tube in the liver, the time of day you give it can make a big difference in how sick the animals get.
Methodology
Rats were infused with FUDR at different times to assess survival and liver toxicity.
Limitations
The study was conducted on rats, which may not fully represent human responses.
Participant Demographics
34 rats, including Sprague Dawley and Fisher strains.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
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