Microbiota and Cytokine Modulation in Cancer Therapy
Author Information
Author(s): Farhadi Rad Hamidreza, Tahmasebi Hamed, Javani Samaneh, Hemati Maral, Zakerhamidi Darya, Hosseini Masoomeh, Alibabaei Farnaz, Banihashemian Seyedeh Zahra, Oksenych Valentyn, Eslami Majid
Primary Institution: Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran
Hypothesis
The gut microbiota plays a crucial role in modulating anticancer immunity and the effectiveness of cancer therapies.
Conclusion
The study highlights the complex interactions between gut microbiota and immune responses, suggesting that microbiome modulation could enhance cancer treatment outcomes.
Supporting Evidence
- The gut microbiota significantly impacts the effectiveness of immunotherapy, chemotherapy, and radiotherapy.
- Certain bacteria can enhance anti-tumor immunity by modifying immune responses.
- Microbial metabolites, like short-chain fatty acids, influence cytokine expression and immune cell activation.
- Fecal microbiota transplantation may improve outcomes in patients resistant to immune checkpoint inhibitors.
Takeaway
The bacteria in our gut can help or hurt our body's ability to fight cancer, so keeping a healthy balance of these bacteria might make cancer treatments work better.
Digital Object Identifier (DOI)
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