Understanding Early Host Responses in Dengue Disease
Author Information
Author(s): Tolfvenstam Thomas, Lindblom Anna, Schreiber Mark J, Ling Ling, Chow Angelia, Ooi Eng Eong, Hibberd Martin L
Primary Institution: Genome Institute of Singapore
Hypothesis
Earlier assessment following symptom presentation would be required to characterize the in-vivo dengue innate immune response.
Conclusion
The early response in patients mimics those previously described in vitro, indicating that several early transcripts may mediate the pathogenesis of dengue disease.
Supporting Evidence
- A strong activation of innate immune response related genes was observed in the early dengue fever phase.
- Transcripts related to adaptive immune response were over-expressed in the second sampling point.
- The most common DENV serotype among patients was DENV3.
Takeaway
When people get dengue fever, their bodies react quickly to fight the virus, and understanding this can help doctors treat the disease better.
Methodology
Whole-blood transcriptional profiling was performed on dengue virus PCR positive patients sampled within 72 hours of fever onset.
Limitations
The study did not include patients who progressed to severe dengue, and the sample size was limited to 31 patients.
Participant Demographics
Patients were adults aged 18 and older, with a mean age of 43 years.
Statistical Information
P-Value
<0.0001
Digital Object Identifier (DOI)
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