Matrix metalloproteinase-19 inhibits growth of endothelial cells by generating angiostatin-like fragments from plasminogen
2011
MMP-19 and Its Role in Inhibiting Endothelial Cell Growth
publication
Evidence: moderate
Author Information
Author(s): Rena Brauer, Inken Beck, Martin Roderfeld, Elke Roeb, Radislav Sedlacek
Primary Institution: Institute of Biochemistry, University of Kiel
Hypothesis
MMP-19 processes plasminogen to generate angiostatin-like fragments that inhibit endothelial cell proliferation.
Conclusion
MMP-19 exhibits an anti-angiogenic effect on endothelial cells via generation of angiostatin-like fragments.
Supporting Evidence
- MMP-19 processes plasminogen to generate three angiostatin-like fragments.
- These fragments inhibited the proliferation of HMEC cells by 27%.
- Capillary-like structure formation was reduced by 45% in treated cells.
Takeaway
MMP-19 helps make pieces from a protein that stop blood vessel growth, which is important for preventing diseases like cancer.
Methodology
The study involved processing human plasminogen with MMP-19 and assessing its effects on endothelial cell proliferation and capillary-like structure formation.
Statistical Information
P-Value
0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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