Testosterone and Frailty in Older Men with HIV
Author Information
Author(s): Jenny Pena Dias, Kathryn C Fitzgerald, Michelle Shardell, Steven Wolinsky, Jordan Lake, Susan L Koletar, Shezhad Basaria, Todd Brown
Primary Institution: Johns Hopkins University
Hypothesis
Hormonal changes in older men with HIV may contribute to the development of frailty.
Conclusion
Low free testosterone levels predict the development of frailty in older men with HIV.
Supporting Evidence
- Older men with HIV have a higher prevalence of frailty than those without HIV.
- Low free testosterone levels were associated with a higher likelihood of becoming frail.
- SHBG concentrations did not predict frailty in this population.
Takeaway
Older men with HIV who have low testosterone are more likely to become frail, while those with higher levels are less likely to have this problem.
Methodology
Free testosterone and SHBG were measured in non-frail men with HIV, and statistical models were used to analyze the data.
Participant Demographics
Mean age was 55 years, with a follow-up period of 8.5 years.
Statistical Information
P-Value
0.03
Confidence Interval
95% CI:1.12, 2.24
Statistical Significance
p=0.03
Digital Object Identifier (DOI)
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