Alpha1A-Adrenergic Receptor Polymorphism and Blood Pressure in Brazilians
Author Information
Author(s): Silvia R Freitas, Alexandre C Pereira, Marcilene S Floriano, José G Mill, José E Krieger
Primary Institution: Heart Institute/InCor, University of São Paulo Medical School
Hypothesis
Is there an association between the Arg347Cys polymorphism in the alpha1A-adrenergic receptor gene and blood pressure phenotypes in the Brazilian population?
Conclusion
The Arg347Cys polymorphism may serve as a biomarker for hypertension risk, particularly in younger individuals and those with regular physical activity.
Supporting Evidence
- The study found a significant association between the Cys/Cys genotype and diastolic blood pressure.
- The presence of the Cys/Cys genotype was marginally associated with hypertension.
- Younger individuals and those with regular physical activity showed a stronger association with hypertension.
Takeaway
This study looked at a gene that might affect blood pressure in people from Brazil, finding that certain gene variations could mean a higher risk of high blood pressure, especially for younger and active people.
Methodology
A cross-sectional study involving genetic analysis of the Arg347Cys polymorphism in 1568 individuals from Vitória, Brazil, using various statistical tests to analyze blood pressure and genotype associations.
Potential Biases
Potential population structure and reduced statistical power for ethnic subgroup analysis.
Limitations
The study's cross-sectional design may limit the ability to establish causation, and blood pressure was measured only once.
Participant Demographics
Individuals aged 25 to 64 years from an urban population in Vitória, Brazil, with a mix of ethnic backgrounds.
Statistical Information
P-Value
0.04
Confidence Interval
1.06–3.26
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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