Impact of EUCAST 2020 Update on Antibiotic Prescriptions for Pseudomonas aeruginosa in Urinary Infections
Author Information
Author(s): Pallotto Carlo, Milani Paolo, Catalpi Caterina, Pietrella Donatella, Curcio Giuseppe, Allegrucci Filippo, Gidari Anna, Svizzeretto Elisabetta, Genga Giovanni, Tommasi Andrea, Mencacci Antonella, Francisci Daniela
Primary Institution: Infectious Diseases Clinic, Santa Maria della Misericordia Hospital, Department of Medicine, University of Perugia, Italy
Hypothesis
The study aims to evaluate the impact of the 2020 EUCAST update on antibiotic prescription in urinary tract infections due to Pseudomonas aeruginosa.
Conclusion
The 2020 EUCAST update may have led to an increase in carbapenem prescriptions and a decrease in anti-Pseudomonas cephalosporins use.
Supporting Evidence
- 65% of urine cultures were associated with asymptomatic bacteriuria.
- Carbapenem prescriptions increased from 21.4% to 41% after the EUCAST update.
- Anti-Pseudomonas cephalosporins prescriptions decreased significantly after the update.
Takeaway
Doctors are trying to use antibiotics better for urinary infections, and new rules are changing how they prescribe them.
Methodology
A retrospective observational study comparing cases of P. aeruginosa isolation from urine before and after the 2020 EUCAST update.
Potential Biases
Potential bias due to the retrospective design and exclusion criteria.
Limitations
The study is retrospective, monocentric, and focused on a specific pathogen.
Participant Demographics
Patients with P. aeruginosa isolation from urine culture admitted to a tertiary care hospital from 2018 to 2021.
Statistical Information
P-Value
p = 0.016
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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