Immediate Delivery vs. Expectant Care for Women with Preterm Rupture of Membranes
Author Information
Author(s): Morris Jonathan M, Roberts Christine L, Crowther Caroline A, Buchanan Sarah L, Henderson-Smart David J, Salkeld Glenn
Primary Institution: Royal North Shore Hospital, University of Sydney
Hypothesis
Is planned early delivery associated with less neonatal and maternal morbidity compared with expectant management in women with preterm prelabour rupture of membranes (PPROM) between 34 and 36 weeks gestation?
Conclusion
The trial aims to provide evidence on the optimal care for women with PPROM close to term, balancing the risks of infection against the risks of prematurity.
Supporting Evidence
- PPROM complicates up to 2% of all pregnancies and is the cause of 40% of all preterm births.
- Expectant management may result in prolonged antenatal hospitalization.
- Immediate delivery was associated with a significant decrease in chorioamnionitis compared to expectant management.
Takeaway
This study is trying to find out if delivering babies early is better than waiting when the water breaks before labor starts.
Methodology
A randomized controlled trial comparing early planned birth with expectant management for women with PPROM between 34 and 36 weeks gestation.
Potential Biases
Potential bias in treatment allocation and participant selection.
Limitations
Insufficient power to detect differences in important endpoints such as neonatal sepsis and respiratory distress.
Participant Demographics
Pregnant women between 34 and 36 weeks gestation with PPROM and a singleton pregnancy.
Statistical Information
P-Value
0.05
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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