Testing for H. pylori Infection with Heliprobe 14C-UBT
Author Information
Author(s): Fariborz Mansour-Ghanaei, Omid Sanaei, Farahnaz Joukar
Primary Institution: Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences
Hypothesis
To study the diagnostic accuracy of Heliprobe 14C-urea breath test (14C-UBT) for detection of H. pylori infection in an Iranian population.
Conclusion
The Heliprobe 14C-UBT is an easy-to-perform, rapid-response, and accurate test for H. pylori diagnosis, suitable for office use.
Supporting Evidence
- The Heliprobe 14C-UBT had 94% sensitivity and 100% specificity compared to gold standard tests.
- The test showed 97% accuracy in diagnosing H. pylori infection.
- 100% positive predictive value and 93% negative predictive value were observed.
Takeaway
Doctors can use a simple breath test to check if someone has a germ called H. pylori that can make their tummy hurt.
Methodology
125 dyspeptic patients underwent gastroscopy and four gastric biopsies, followed by a Heliprobe 14C-UBT test.
Limitations
The study excluded patients on certain medications and those with severe health conditions, which may limit generalizability.
Participant Demographics
Patients aged 15 to 75, with 52% females and 48% males, mean age 35.81 years.
Statistical Information
Confidence Interval
95% CI: 85–98%
Digital Object Identifier (DOI)
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