Circulating T Cells as Indicators of Breast Cancer Status
Author Information
Author(s): Chen Han‐Kun, Chen Yi‐Ling, Chung Wei‐Pang, Loh Zhu‐Jun, Lee Kuo‐Ting, Hsu Hui‐Ping
Primary Institution: National Cheng Kung University Hospital
Hypothesis
Circulating immune cells potentially indicate breast cancer status.
Conclusion
Circulating CD3+CD8+ CTL levels are promising biomarkers for breast cancer management.
Supporting Evidence
- Circulating CD3+CD8+ CTL levels were lower in breast cancer patients compared to healthy controls.
- Post-treatment, CD3+CD8+ CTL levels increased, then decreased upon recurrence.
- Elevated plasma CCL2 levels distinguished breast cancer patients from healthy controls.
Takeaway
Doctors can check certain blood cells to see how breast cancer is doing and if treatment is working.
Methodology
Flow cytometry was used to analyze circulating immune cell profiles in breast cancer patients and healthy controls.
Limitations
The study had a relatively small patient cohort and interindividual variation in immune cell types.
Participant Demographics
Median age of healthy controls was 40 years, and 52 years for breast cancer patients.
Statistical Information
P-Value
0.038
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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