Using IMGT unique numbering for IG allotypes and Fc‐engineered variants of effector properties and half‐life of therapeutic antibodies
2024
Therapeutic Antibodies and Their Properties
publication
Evidence: high
Author Information
Author(s): Marie‐Paule Lefranc, Gérard Lefranc
Primary Institution: Université de Montpellier
Hypothesis
How do modifications in therapeutic antibodies affect their effector properties and half-life?
Conclusion
The study provides a comprehensive overview of the classification and properties of therapeutic antibodies, emphasizing the importance of IMGT nomenclature.
Supporting Evidence
- Therapeutic antibodies can be engineered to enhance their effectiveness.
- IMGT nomenclature provides a standardized way to classify antibody variants.
- Understanding the structural features of antibodies helps in improving their therapeutic properties.
Takeaway
This study explains how scientists categorize and modify therapeutic antibodies to make them work better in treating diseases.
Digital Object Identifier (DOI)
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