Chemotherapy and Radiation for Nasopharyngeal Cancer
Author Information
Author(s): Dechaphunkul Tanadech, Pruegsanusak Kowit, Sangthawan Duangjai, Sunpaweravong Patrapim
Primary Institution: Prince of Songkla University
Hypothesis
This study aimed to evaluate the effectiveness and safety of concurrent chemoradiotherapy with carboplatin followed by carboplatin and 5-fluorouracil in patients with locally advanced nasopharyngeal carcinoma.
Conclusion
The study found that concurrent chemoradiotherapy with carboplatin followed by carboplatin and 5-fluorouracil is an effective treatment option for locally advanced nasopharyngeal carcinoma, showing good overall response and survival rates.
Supporting Evidence
- 100% of patients achieved an objective response rate of the primary tumor.
- The 3-year overall survival rate was 89.7%.
- The 3-year progression-free survival rate was 72.7%.
- Weight loss and mucositis were the most common acute toxicities.
Takeaway
Doctors used a special treatment with two types of medicine and radiation to help people with a throat cancer called nasopharyngeal carcinoma, and it worked really well for most of them.
Methodology
A prospective study involving 50 patients who received radiation therapy and concurrent chemotherapy with carboplatin, followed by adjuvant chemotherapy with carboplatin and 5-fluorouracil.
Limitations
The study was limited to a single institution and had a relatively small sample size.
Participant Demographics
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Digital Object Identifier (DOI)
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