Huntington's Disease: An Immune Perspective
2011
Huntington's Disease: An Immune Perspective
publication
Evidence: moderate
Author Information
Author(s): Nayak Annapurna, Ansar Rafia, Verma Sunil K., Bonifati Domenico Marco, Kishore Uday
Primary Institution: Centre for Infection, Immunity and Disease Mechanisms, Brunel University
Hypothesis
The effects of immune activation in the Huntington's disease nervous system are a relatively unexplored area of research.
Conclusion
The study highlights the role of immune activation and neuroinflammation in the progression of Huntington's disease.
Supporting Evidence
- Huntington's disease is caused by an abnormal expansion of CAG trinucleotide repeats.
- Neuroinflammation is a typical feature of Huntington's disease.
- Activated microglial cells are associated with neuronal dysfunction in Huntington's disease.
- Chronic neuroinflammation can exacerbate neuronal damage in Huntington's disease.
Takeaway
Huntington's disease is a brain disorder that affects movement and thinking, and it involves problems with the immune system that can make the disease worse.
Digital Object Identifier (DOI)
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