Infarct Tissue Heterogeneity as a Predictor of Mortality in Heart Disease
Author Information
Author(s): Watanabe Eri, Coelho-Filho Otavio Rizzi, Mongeon François-Pierre, Jerosch-Herold Michael, Abdullah Shuaib M, Blankstein Ron, Hatabu Hiroto, Mandry Damien, Heydari Bobby, van der Geest Rob J, Kwong Raymond Y
Primary Institution: Brigham and Women's Hospital, Boston, MA, USA
Hypothesis
Infarct heterogeneity by CMR provides strong association with patient mortality beyond LVEF.
Conclusion
Infarct heterogeneity measured as %PIZ is strongly associated with patient mortality, particularly in patients with a LVEF of 30-60%.
Supporting Evidence
- LGE was present in 297 patients (75%).
- Mean total infarct mass was 19±23g (14% of LV mass).
- Mean %PIZ was 19±17%.
- 73 patients (19%) died during the follow-up period.
- %PIZ was one of the strongest univariable predictors of mortality.
- The hazard increased by 25% per 10% %PIZ increase.
- In the 304 patients with LVEF>30%, %PIZ demonstrated a robust association with mortality.
Takeaway
Doctors can use a special MRI to see how different parts of the heart are damaged, which helps them understand how likely a patient is to survive.
Methodology
The study involved 404 patients with CAD and LVEF <60%, using CMR to assess infarct heterogeneity and follow-up for mortality.
Potential Biases
Potential biases related to patient selection and follow-up methods.
Limitations
The study is observational and may not account for all confounding factors.
Participant Demographics
76% males, mean age 60±12 years.
Statistical Information
P-Value
0.0004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website