Boswellia serrata Gum Resin Reduces Kidney Damage
Author Information
Author(s): Eltahir Heba M., Shalkami Abdel-Gawad S., Shehata Ahmed M., Almikhlafi Mohannad, Aldhafiri Ahmed J., Alalawi Ali, Albadrani Muayad, Mahmoud Ahmad Bakur, Abouzied Mekky M.
Primary Institution: Taibah University
Hypothesis
Can Boswellia serrata gum resin extract mitigate renal toxicity caused by CCl4?
Conclusion
Boswellia serrata gum resin extract shows significant potential in reducing renal damage and fibrosis caused by CCl4.
Supporting Evidence
- BS treatment improved renal function markers and antioxidant status.
- Inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 levels were significantly reduced with BS treatment.
- Histological examination showed improved kidney tissue after BS treatment.
Takeaway
This study found that a natural substance from the Boswellia serrata tree can help protect kidneys from damage caused by a harmful chemical.
Methodology
Male Wistar albino rats were divided into groups and treated with CCl4 to induce renal toxicity, followed by treatment with Boswellia serrata or Silymarin.
Limitations
The study compared Boswellia serrata to Silymarin, but the efficacy of Silymarin is controversial.
Participant Demographics
Male Wistar albino rats, weighing 200–250 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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