Fluoroquinolone Resistance in Streptococcus pneumoniae in Hong Kong
Author Information
Author(s): Pak Leung Ho, Wing Cheong Yam, Terence K.M. Cheung, Wilson W.S. Ng, Tak Lun Que, Dominic N.C. Tsang, Tak Keung Ng, Wing Hong Seto
Primary Institution: University of Hong Kong
Hypothesis
What is the serotype distribution and resistance pattern of Streptococcus pneumoniae in Hong Kong?
Conclusion
The study found that fluoroquinolone-resistant strains of Streptococcus pneumoniae in Hong Kong are closely related to the Spanish 23F clone.
Supporting Evidence
- 73% of the isolates were serotypes 6A/B, 19F, and 23F.
- 15 of the 140 isolates were resistant to ciprofloxacin.
- All ciprofloxacin-resistant strains were from adults aged 54 to 88 years.
Takeaway
This study looked at bacteria that cause pneumonia in Hong Kong and found that many of them are resistant to important antibiotics.
Methodology
The study analyzed sputum isolates from four regional laboratories in Hong Kong using pulsed-field gel electrophoresis.
Limitations
The study only included isolates from hospitalized patients and did not sample children aged 6 to 17 years.
Participant Demographics
Isolates were obtained from hospitalized patients, primarily adults aged 54 to 88 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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