High Anion Gap Metabolic Acidosis and 5-Oxoprolinuria in a Hospital Setting Induced by Acetaminophen, Sepsis, and Malnutrition: A Case Report
Author Information
Author(s): Muacevic Alexander, Adler John R, Al-saedi Zainulabdeen, Miqdad Mohammed A, Alatta Lina, Spinowitz Bruce, Kuo Sheng
Primary Institution: NewYork-Presbyterian Queens, New York, USA
Hypothesis
Can 5-oxoprolinuria be a significant cause of high anion gap metabolic acidosis in critically ill patients?
Conclusion
The case highlights the importance of recognizing 5-oxoprolinuria as a potential cause of metabolic acidosis in patients with sepsis and malnutrition.
Supporting Evidence
- 5-oxoproline acidosis is increasingly recognized in critically ill patients.
- The patient had a history of normal kidney function before hospitalization.
- Despite treatment, the patient exhibited persistent high anion gap metabolic acidosis.
- Elevated urine 5-oxoproline levels were identified, leading to a change in treatment.
- N-acetylcysteine therapy was initiated to address the metabolic acidosis.
Takeaway
This study is about a sick man who got very ill from a medicine called acetaminophen, and doctors found out he had a special problem that made his body too acidic.
Methodology
Case report detailing the clinical course and management of a patient with high anion gap metabolic acidosis.
Limitations
The study is based on a single case report, limiting generalizability.
Participant Demographics
29-year-old male with a history of intellectual disability.
Digital Object Identifier (DOI)
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