Impact of Hormone Receptors on Breast Cancer Outcomes
Author Information
Author(s): J.M.T. Howat, M. Harris, R. Swindell, D. M. Barnes
Primary Institution: North Manchester General Hospital; Christie Hospital & Holt Radium Institute
Hypothesis
Do oestrogen and progesterone receptors affect recurrence and survival in breast cancer patients?
Conclusion
Patients with oestrogen receptors have better survival rates after mastectomy compared to those without.
Supporting Evidence
- Patients with REc had a significantly longer survival following mastectomy than those without it.
- Post-menopausal patients with REc showed the most marked improvement in survival.
- Patients with both REc and RPc survived longer after relapse than those without either receptor.
Takeaway
Women with certain hormone receptors in their breast cancer tend to live longer after surgery than those without these receptors.
Methodology
The study measured hormone receptor levels in breast cancer patients and followed their outcomes after surgery.
Limitations
The study did not confirm that hormone receptor status can reliably predict early relapse in breast cancer.
Participant Demographics
175 women with operable breast cancer, excluding those with bilateral tumors or distant metastases.
Statistical Information
P-Value
P=0.006 for survival with REc, P=0.03 for node-positive patients with REc.
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