The Role of Treatment Choice in Hashimoto's Disease and Alzheimer's Disease
Author Information
Author(s): Gorbunova Galina, Yashkin Arseniy, Nikitin Stanislav Kolpakov, Ukraintseva Svetlana, Yashin Anatoliy, Akushevich Igor
Primary Institution: Duke University
Hypothesis
Hypothyroidism treatment modalities may cause variability in the available evidence of a hypothyroidism-Alzheimer's disease association.
Conclusion
The association between Hashimoto's disease and Alzheimer's disease changes when treatment modalities are considered.
Supporting Evidence
- Alzheimer's disease is most prevalent at advanced ages.
- Hyperthyroidism has been associated with an increased risk of cognitive decline.
- Non-treatment-enabled models found no significant association between Hashimoto's disease and Alzheimer's disease.
Takeaway
This study looked at how different treatments for hypothyroidism might affect the link between Hashimoto's disease and Alzheimer's disease. It found that considering treatment options changes the results.
Methodology
Used Medicare administrative claims data from 2006-2022 to assess the association between Hashimoto's disease and Alzheimer's disease with treatment modalities included.
Limitations
The prediction power of treatment-aware models was substantially weaker due to stratification.
Participant Demographics
Findings were consistent across sex/gender and race/ethnicity-specific groups.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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