Effects of Low Protein Diet During Pregnancy on Male Rat Development
Author Information
Author(s): Toledo Fabíola C, Perobelli Juliana E, Pedrosa Flávia PC, Anselmo-Franci Janete A, Kempinas Wilma DG
Primary Institution: University of Campinas - UNICAMP
Hypothesis
Does in utero protein restriction affect the sexual development and reproductive function of male rats?
Conclusion
In utero protein restriction causes growth delay and alters male reproductive-system programming in rats, leading to reduced sperm quality in adulthood.
Supporting Evidence
- In utero protein restriction reduced body weight of male pups at various developmental stages.
- Sertoli cell number and sperm motility were significantly lower in rats subjected to protein restriction.
- Higher rates of sperm with morphological abnormalities were observed in the hypoproteic group.
Takeaway
When baby rats don't get enough protein while they're growing in their mom's belly, they can grow up to have problems with their sperm and overall health.
Methodology
Pregnant Wistar rats were divided into two groups: one received standard chow and the other received hypoproteic chow during gestation, with male offspring assessed at different developmental stages.
Potential Biases
Potential bias in the selection of experimental groups and the assessment methods used.
Limitations
The study was conducted on rats, which may not fully represent human physiology.
Participant Demographics
Wistar rats, with 20 adult females and 10 adult males used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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