Roles of XB130, a novel adaptor protein, in cancer
2011
Roles of XB130 in Cancer
publication
Evidence: moderate
Author Information
Author(s): Shiozaki Atsushi, Liu Mingyao
Primary Institution: Kyoto Prefectural University of Medicine
Hypothesis
XB130 plays important roles in the regulation of signal transduction, cell proliferation, survival, motility, and invasion in cancer.
Conclusion
XB130 is a novel oncoprotein that influences tumor progression by affecting cell proliferation, survival, motility, and invasion in various cancer cells.
Supporting Evidence
- XB130 down-regulation reduced c-Src activity and IL-8 production in lung cancer cells.
- Knockdown of XB130 inhibited cell cycle progression and induced apoptosis in thyroid cancer cells.
- XB130 is involved in the motility and invasiveness of cancer cells.
Takeaway
XB130 is a protein that helps cancer cells grow and move around, and understanding it better could help us find new ways to treat cancer.
Methodology
The study involved molecular cloning, gene expression profiling, and in vivo experiments using xenograft models.
Digital Object Identifier (DOI)
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