Regular use of analgesics is a risk factor for renal cell carcinoma
1999
Analgesics and Kidney Cancer Risk
Sample size: 1204
publication
Evidence: moderate
Author Information
Author(s): Gago-Dominguez M, Yuan J-M, Castelao J E, Ross R K, Yu M C
Primary Institution: University of Southern California
Hypothesis
Is regular use of analgesics a risk factor for renal cell carcinoma?
Conclusion
Regular use of analgesics is associated with an increased risk of renal cell carcinoma.
Supporting Evidence
- Regular use of analgesics was a significant risk factor for RCC in both men and women.
- Individuals in the highest exposure categories exhibited approximately 2.5-fold increase in risk relative to non- or irregular users of analgesics.
- Subjects taking one regular-strength aspirin a day or less were not at increased risk of RCC.
Takeaway
Taking pain relievers regularly might make you more likely to get kidney cancer.
Methodology
A population-based case–control study with in-person interviews to collect medical and medication histories.
Participant Demographics
Non-Asian RCC patients aged 25–74 and matched controls.
Statistical Information
Confidence Interval
95% CI = 1.4–1.9
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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