Human Salmonella Infection with CTX-M β-Lactamase
Author Information
Author(s): Sjölund Maria, Yam Jennifer, Schwenk Jillian, Joyce Kevin, Medalla Felicita, Barzilay Ezra, Whichard Jean M.
Primary Institution: Centers for Disease Control and Prevention
Hypothesis
Is there a domestically acquired CTX-M–producing Salmonella isolate in the United States?
Conclusion
A domestically acquired CTX-M–producing Salmonella isolate was identified in a 3-month-old boy in Georgia.
Supporting Evidence
- Among 1,864 human NTS isolates, 105 displayed elevated MICs to ceftriaxone or ceftiofur.
- The isolate was confirmed to be a CTX-M–producing Salmonella ser. Typhimurium.
- The patient had diarrhea and fever but recovered without complications.
Takeaway
Doctors found a type of Salmonella that is resistant to some antibiotics in a baby from Georgia, and it didn't come from outside the country.
Methodology
The study involved testing Salmonella isolates submitted to the CDC for antibiotic resistance using broth microdilution.
Limitations
The study only reports on one case and does not provide a broader analysis of CTX-M prevalence.
Participant Demographics
The patient was a 3-month-old white, non-Hispanic boy from Georgia.
Digital Object Identifier (DOI)
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