Using PET Imaging and Gamma Probes to Find Colorectal Cancer Recurrences
Author Information
Author(s): Sarikaya Ismet, Povoski Stephen P, Al-Saif Osama H, Kocak Ergun, Bloomston Mark, Marsh Steven, Cao Zongjian, Murrey Douglas A, Zhang Jun, Hall Nathan C, Knopp Michael V, Martin Edward W Jr
Primary Institution: The Ohio State University
Hypothesis
Combining intraoperative gamma probe detection with preoperative FDG-PET imaging will improve detection of tumor recurrence in colorectal cancer patients.
Conclusion
The combined use of preoperative FDG-PET and intraoperative gamma probe detection is helpful for accurately locating tumor recurrences in colorectal cancer patients.
Supporting Evidence
- Preoperative FDG-PET detected 48 lesions, while intraoperative gamma probe detected 45 lesions.
- 37 out of 50 resected sites were confirmed as tumor positive.
- Both imaging techniques accurately detected 29 of 37 pathologically proven tumor sites.
Takeaway
Doctors used two special imaging techniques to find cancer that might come back in patients, helping them see where the cancer is hiding.
Methodology
Patients underwent preoperative FDG-PET scans and intraoperative gamma probe studies to detect tumor recurrence.
Potential Biases
Potential for false positives due to physiological uptake of FDG in non-cancerous tissues.
Limitations
The study may not account for all variables affecting detection accuracy, such as the size of lesions.
Participant Demographics
Mean age of participants was 54 years, with 12 females and 9 males.
Statistical Information
P-Value
0.00021
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website