Yeast UBL-UBA proteins have partially redundant functions in cell cycle control
2006
Yeast UBL-UBA proteins and their roles in cell cycle control
publication
Evidence: moderate
Author Information
Author(s): Laura A Díaz-Martínez, Yang Kang, Kylie J Walters, Duncan J Clarke
Primary Institution: University of Minnesota
Hypothesis
Do the UBL-UBA proteins in yeast act redundantly in cell cycle control?
Conclusion
The three yeast UBL-UBA proteins have partially redundant roles required for progression through mitosis.
Supporting Evidence
- RAD23 is redundant with DDI1 and DSK2.
- The triple deletion strain delays in G2/M-phase and mid-anaphase at high temperatures.
- Cell cycle progression can only be partially rescued by a rad23 allele lacking the c-terminal UBA domain.
- Ddi1 homodimerization is necessary for its cell cycle related functions.
Takeaway
There are three proteins in yeast that help control how cells divide, and they can do some of the same jobs, but not all of them.
Methodology
Genetic approach using strains deleted for each UBL-UBA gene and their combinations.
Limitations
The study did not explore all potential interactions and effects of the UBL-UBA proteins.
Digital Object Identifier (DOI)
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