P-glycoprotein Expression in Neuroblastoma
Author Information
Author(s): M. Favrot, V. Combaret, E. Goillot, J.P. Wagner, E. Bouffet, F. Mazingue, A. Thyss, P. Bordigoni, G. Delsol, C. Bailly, B. Fontanier, T. Philip
Primary Institution: Centre Leon Berard
Hypothesis
Is P-glycoprotein expression associated with chemoresistance in neuroblastoma?
Conclusion
P-glycoprotein expression was found only in normal cells within neuroblastoma specimens, suggesting it does not play a significant role in chemoresistance.
Supporting Evidence
- Malignant cells were negative for P-glycoprotein in all specimens.
- Normal infiltrating cells expressed P-glycoprotein in some biopsies.
- Chemotherapy did not correlate with P-glycoprotein expression in malignant cells.
Takeaway
The study looked at cancer samples and found that a protein linked to drug resistance was only in normal cells, not in the cancer cells themselves.
Methodology
Immunohistological detection of P-glycoprotein was performed on serial sections of neuroblastoma specimens.
Limitations
The study's findings may be influenced by contamination of tumor samples with normal tissues.
Want to read the original?
Access the complete publication on the publisher's website