Synthesis of Amine-Linked Diglycosides
Author Information
Author(s): Ian Cumpstey, Jens Frigell, Elias Pershagen, Tashfeen Akhtar, Elena Moreno-Clavijo, Inmaculada Robina, Dominic S. Alonzi, Terry D. Butters
Primary Institution: Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University
Hypothesis
Amine-linked diglycose derivatives may act as glycosidase inhibitors.
Conclusion
The synthesized amine-linked diglycosides showed weak glycosidase inhibitory activity.
Supporting Evidence
- The study synthesized diglycose derivatives linked by nitrogen.
- The synthesis involved converting carbohydrates into unsaturated derivatives to enhance reactivity.
- The synthesized compounds showed weak inhibitory activity against glycosidases.
Takeaway
The researchers made new sugar-like molecules that are linked by nitrogen and tested them to see if they could stop certain enzymes, but they didn't work very well.
Methodology
The study involved synthesizing amine-linked diglycosides using Mitsunobu coupling and palladium-catalyzed reactions, followed by glycosidase inhibition assays.
Limitations
The glycosidase inhibitory activity of the compounds was weak, and the nature of the binding and basis for inhibition is not clear.
Digital Object Identifier (DOI)
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