Notch3's Role in T Cell Development and Leukemogenesis
Author Information
Author(s): Suliman Sara, Tan Joanne, Xu Keli, Kousis Philaretos C., Kowalski Paul E., Chang Greg, Egan Sean E., Guidos Cynthia
Primary Institution: Hospital for Sick Children Research Institute
Hypothesis
Is Notch3 necessary for thymocyte β-selection and Notch1-induced T cell leukemogenesis?
Conclusion
Notch3 is not required for thymocyte β-selection or for T cell leukemogenesis induced by Notch1.
Supporting Evidence
- N3-deficient DN3 thymocytes were not defective in generating DP thymocytes.
- N3 deficiency did not exacerbate the competitive defect of N1+/− DN3 progenitors.
- N3 deficiency did not alter the incidence or latency of T-LL induced by ICN1.
Takeaway
The study found that Notch3 is not needed for T cell development or cancer caused by Notch1, even though it is present in T cells.
Methodology
Mice lacking Notch3 were generated and analyzed for T cell development and leukemogenesis.
Limitations
The study primarily focused on the role of Notch3 without exploring potential compensatory mechanisms by other Notch receptors.
Statistical Information
P-Value
p=0.4
Statistical Significance
p=0.4
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website