2-Methyl-6-nitro-2H-indazole
2011
Crystal Structure of 2-Methyl-6-nitro-2H-indazole
publication
Evidence: moderate
Author Information
Author(s): Long Li, Liu Bing-Ni, Liu Mo, Liu Deng-Ke
Primary Institution: Tianjin Polytechnic University
Hypothesis
The study aims to report the crystal structure of 2-Methyl-6-nitro-2H-indazole, an intermediate in the synthesis of the antitumor agent pazopanib.
Conclusion
The crystal structure of the compound shows that it has a nearly planar molecular skeleton with weak intermolecular hydrogen bonds contributing to its packing.
Supporting Evidence
- The molecular skeleton of the compound is almost planar.
- Weak intermolecular hydrogen bonds help establish the packing in the crystal.
- The study provides a detailed analysis of the bond lengths and angles in the compound.
Takeaway
This study looks at a special chemical structure that could help make a medicine for cancer. It shows how the parts of the molecule fit together.
Methodology
The compound was synthesized and analyzed using X-ray crystallography.
Digital Object Identifier (DOI)
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