Prevention of Ovarian Hyperstimulation Syndrome with Intravenous Fluids
Author Information
Author(s): Youssef MA, Al-Inany HG, Evers JL, Aboulghar M
Hypothesis
Does the administration of intravenous fluids prevent severe ovarian hyperstimulation syndrome (OHSS) in women undergoing IVF or ICSI treatment cycles?
Conclusion
The use of hydroxyethyl starch significantly decreases the incidence of severe OHSS in high-risk women undergoing IVF or ICSI treatment cycles.
Supporting Evidence
- Nine RCTs involving 1660 women were included in the review.
- There was a statistically significant decrease in severe OHSS incidence with administration of hydroxyethyl starch.
- Borderline statistically significant decrease in the incidence of severe OHSS with administration of human albumin.
Takeaway
Giving certain fluids to women during fertility treatments can help prevent a serious condition called ovarian hyperstimulation syndrome.
Methodology
Nine RCTs involving 1660 women for human albumin and 487 for hydroxyethyl starch were included in the review.
Limitations
Limited evidence of benefit from intravenous albumin administration; no studies on other potential intravenous fluids.
Participant Demographics
High-risk women undergoing IVF or ICSI treatment cycles.
Statistical Information
P-Value
0.01
Confidence Interval
95% CI 0.45 to 0.99
Statistical Significance
p=0.01
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