The Tibetan Uterotonic Zhi Byed 11: Mechanisms of Action, Efficacy, and Historical Use for Postpartum Hemorrhage
Author Information
Author(s): Coelius Rebecca Lynn, Stenson Amy, Morris Jessica L., Cuomu Mingji, Tudor Carrie, Miller Suellen
Primary Institution: University of California, San Francisco
Hypothesis
To explore evidence for the traditional Tibetan medicine, Zhi Byed 11 (ZB11), for use as a uterotonic.
Conclusion
ZB11 is a potentially effective uterotonic for preventing postpartum hemorrhage, especially in low-resource settings.
Supporting Evidence
- ZB11 has been used for over 700 years in Tibetan medicine.
- It is affordable at USD 0.04 per dose and does not require special storage.
- A recent RCT showed ZB11's efficacy comparable to misoprostol in reducing severe postpartum hemorrhage.
- ZB11 has a low side effect profile compared to misoprostol.
Takeaway
Zhi Byed 11 is a traditional Tibetan medicine that helps women after childbirth to stop heavy bleeding.
Methodology
The study involved a double-blind, randomized controlled trial comparing ZB11 to misoprostol in three maternity hospitals.
Limitations
The study only reviewed three databases and did not include Chinese databases due to language barriers.
Participant Demographics
Women delivering in three maternity hospitals in Lhasa, TAR.
Statistical Information
P-Value
0.02
Statistical Significance
p = 0.02
Digital Object Identifier (DOI)
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